The article provides data on modern approaches to the treatment of patients with severe uncontrolled bronchial asthma with an emphasis on the use of dupilumab. a human recombinant monoclonal antibody to the alpha subunit of the interleukin (IL)-4 receptor. which inhibits signal transmission from both IL-4 and IL-13. The results of dupilumab pivotal randomized clinical trials DRI12544. https://www.bekindtopets.com/hot-mega-Jeffers-Economy-600D-Royal-Blue-Teal-Plaid-Horse-Blanket-super-sale/