ObjectivesTo report the first and largest systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression (TRD) or major depressive disorder(MDD). MethodsWe conducted a systematic literature retrieval via PubMed. Embase. Web of Science. https://www.diegojavierfares.com/