Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment ... https://yassern431ktb8.blgwiki.com/user