Note that below these situations there may be pain both with no stimulus or with a very gentle, non-tissue-detrimental stimulus. Absolutely nothing is known regarding how these stimuli activate nociceptors. The nociceptive nerve endings are so tiny and scattered that they are difficult to locate, let alone study. Nevertheless, https://www.proleviate.com/post/conolidine-blocks-ackr3-pain-receptors-in-what-way